MetaoThin Active Ingredients Research

MetaboThin XL 90’s diet pills’ active ingredients may be more effective than caffeine alone because Guarana contains other compounds that may also be beneficial for weight loss including small amounts of theobromine, theophylline and catechins, as well as high tannin content (5-8.5%).

  • Caffeine, theobromine and theophylline are all methylxanthines – compounds that are known for their stimulating effects. Meanwhile, catechins and tannins are polyphenols – organic compounds found in plants that have a number of health benefits.

Guarana_MetabothinGuarana’s Potential Fat-Burning Bio-Activities

Guarana is believed to aid weight loss through the combined biological activities of 5 key components:

  1. Caffeine
  2. Theobromine
  3. Theophylline
  4. Tannins
  5. Catechins.

Fat Oxidation & Metabolism Support

Caffeine – Guarana’s major active ingredient – is believed to aid weight loss through 3 main actions: increasing fat oxidation (the body’s usage of fat for energy), enhancing metabolism by increased energy expenditure, and enhancing the effectiveness of exercise.

These effects are achieved through a number of complex mechanisms which include:

  • Inhibition of the enzyme phosphodiesterase
  • Blockade of receptors for adenosine, a compound responsible for suppressing lipolysis (fat breakdown)
  • Countering sleepiness and increasing serotonin and dopamine levels, neurotransmitters associated with happiness and well-being.

Meanwhile, research shows that both theophylline and theobromine are believed to function similarly to caffeine, since they belong to the same group of stimulant compounds.

Fat-Binding Functions

Tannins may also possibly play a role in Guarana’s bio-activity, but few human trials have been done. Studies in animals suggest that tannins may aid in weight loss by binding proteins and carbohydrates into indigestible forms, and also by directly binding to digestive enzymes.

Energy Expenditure

Finally, catechins may also play a role in Guarana’s bio-activities by enhancing energy expenditure and fat oxidation, similar to caffeine. They are believed to work by inhibiting the enzyme COMT, which plays a role in degradation of catecholamines – compounds such as epinephrine that play a role in regulating fat tissue, and also by inhibiting several enzymes used to digest fat.

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Refernces:

  • Heckman MA. et al. Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. J Food Sci. 2010 Apr;75(3):R77-87
  • Andersen T. and Fogh J. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutr Diet. 2001 Jun;14(3):243-50.
  • Hursel R. et al. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev. 2011 Jul;12(7):e573-81
  • Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807.
  • Belza A, Toubro S, Astrup A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur J Clin Nutr. 2009 Jan;63(1):57-64
  • Martínez-Pinilla E. Oñatibia-Astibia A, Franco R. The relevance of theobromine for the beneficial effects of cocoa consumption. Front Pharmacol. 2015; 6: 30.
  • Peters EJ, Klein S, Wolfe RR. Effect of short-term fasting on the lipolytic response to theophylline. Am J Physiol. 1991 Oct;261(4 Pt 1):E500-4.
  • Awika JM, Rooney LW. Sorghum phytochemicals and their potential impact on human health. Phytochemistry. 2004 May;65(9):1199-221.
  • Nagao T. et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr. 2005 Jan;81(1):122-9.
  • Awika JM, Rooney LW. Sorghum phytochemicals and their potential impact on human health. Phytochemistry. 2004 May;65(9):1199-221.
  • Lima WP. et al. Lipid metabolism in trained rats: effect of guarana (Paullinia cupana Mart.) supplementation. Clin Nutr. 2005 Dec;24(6):1019-28.
  • Bérubé-Parent S. et al. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br J Nutr. 2005 Sep;94(3):432-6.
  • Krewer Cda C. et al. Habitual intake of guaraná and metabolic morbidities: an epidemiological study of an elderly Amazonian population. Phytother Res. 2011 Sep;25(9):1367-74.
  • Nagao T. et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr. 2005 Jan;81(1):122-9.
  • De la Garza AL. et al. Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment. Planta Med. 2011 May;77(8):773-85